Following the shift from traditional didactic classroom models to the adoption of more learner-centred active learning approaches, escape rooms are gaining popularity as alternative learning and assessment environments designed to enhance students’ learning and 21st century skills in primary, secondary, higher education, and professional development programs. An educational escape room (EER) can be defined as an instructional method requiring learners to participate in collaborative playful activities explicitly designed for domain knowledge acquisition, skill development or behavioural change so that they can accomplish a specific goal (e.g., escape from a physical or virtual room, solve a murder mystery, or break into a vault) by solving puzzles linked to unambiguous learning objectives in a limited amount of time. Research indicates that, due to their playful nature which favours positive behaviour, EERs can enhance learners’ motivation, engagement, and time management, increase confidence in critical thinking and decision-making, improve knowledge acquisition and academic performance. They can also encourage social interaction, which is very important in the new era of increased hybrid delivery brought upon by COVID-19.